This volume brings together the papers delivered at the international conference Paragone. Leonardo in Context, held in July 2019 at the University of Leipzig, as well as an additional essay by Martin Kemp on Leonardo's sfumato. For this publication, the original conference title was slightly modified to Paragone. Leonardo in Comparison, in order to do justice to the comparative character of the studies it presents and the importance of comparison as a methodological paradigm. A discussion of this is found in the introduction, which at the same time seeks, by way of example, to apply the comparative paradigm to currently the most contentious issue in Leonardo scholarship: the artist's design for a Christ as Salvator Mundi.