Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

Daniel Otzen is professor of nanobiotechnology at the Interdisciplinary Nanoscience Center (iNANO) at Aarhus University, Denmark. He obtained his PhD at Aarhus University in 1995 after studies at the lab of Sir Alan Fersht, University of Cambridge, using protein engineering to dissect the folding pathways of model proteins. He has also worked as a staff scientist at Novozymes A/S within the field of stability and folding of industrial enzymes. In 2000 he established his own research group. His interests include pathological and functional amyloid formation, the structures and properties of pre-fibrillar species, approaches to prevent aggregation and oligomer formation and also the folding and stability of membrane proteins. He is a member of the Danish Royal Society of Sciences and Letters.

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