InhaltsangabeDrug Resistance: The Clinical Perspective D. Alan Anthoney and Stanley B. Kaye Cell Sensitivity Assays: Clonogenic Assay Jane A. Plumb Cell Sensitivity Assays: The MTT Assay Jane A. Plumb Cell Sensitivity Assays: Detection of Apoptotic Cells In Vitro Using the TUNEL Assay Neil A. Jones and Caroline Dive Analysis of Apoptosis in Tissue Sections Vicki Save, Philip J. Coates, and Peter A. Hall Measurement of P-glycoprotein Function Henk J. Broxterman Measuring MDR-1 by Quantitative RT-PCR Susan E. Bates, Zhirong Zhan, Joanna Regis, and Erick Gamelin Microtiter Plate Technique for the Measurement of Glutathione in Fresh and Cryopreserved Lymphoblasts Using the Enzyme Recycling Method Pamela R. Kearns and Andrew G. Hall Measurement of Reduced Glutathione Using High Pressure Liquid Chromatography Linda A. Hogarth, Celia M. A. Rabello, and Andrew G. Hall Topoisomerase I and II Activity Assays Philippe Pourquier, Glenda Kohlhagen, Li-Ming Ueng, and Yves Pommier 5Fluorouracil Metabolizing Enzymes Howard L. McLeod, Lesley H. Milne, and Stephen J. Johnston Measuring DNA Adducts by Immunoassay (ELISA) Michael J. Tilby Measuring Drug-DNA Adducts in Individual Cells Adrian J. Frank Measurement of Drug-Induced DNA Interstrand Crosslinking Using the Single Cell Electrophoresis (Comet) Assay Victoria J. Spanswick, Janet M. Hartley, Timothy H. Ward, and John A. Hartley PCR Analysis of Microsatellite Instability Gillian L. Hirst O 6AlkylguanineDNA Alkyltransferase Assay Amanda J. Watson and Geoffrey P. Margison Analysis of the p53 Status of Tumors: An Overview of Methods Jonas Bergh Bcl2 Family Immunohistochemistry Lloyd R. Kelland and Philip J. Beale Genetic Analysis of Drug Resistance by Fluorescence In Situ Hybridization W. Nicol Keith Genetic Analysis of Drug Resistance by ReverseIn Situ Hybridization W. Nicol Keith Index